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These biomarkers related to chronic oxidative stress and inflammation were significantly abnormal at baseline in the BH4 treatment participants as compared to those who received placebo

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Urinary exosome-specific markers, including mRNA kelch domain containing 7B, caspase 14 (CASP14), protease serine1 (PRSS1) and lncRNAs MIR205 host gene (MIR205HG) and growth arrest specific 5 (GAS5), have been found to be associated with BCa stage, grade and degree of hematuria (207)

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